dbGaP Genotypes Curator

Location: NIH/NCBI - Bethesda, Maryland
Job Code: GAPGC0618
# of openings: 1

Description

Computercraft seeks a computational biologist with a background in genotype analysis to work with National Center for Biotechnology Information (NCBI) scientists to develop infrastructure to analyze large-scale genomic data with clinical phenotype data. The successful candidate will support the NCBI database on Genotypes and Phenotypes (dbGaP), accessible online at https://www.ncbi.nlm.nih.gov/gap. Our scientists work on site at the National Institutes of Health (NIH) in Bethesda, MD, in a production-oriented, rather than research-oriented, environment.

dbGaP was developed to archive and distribute the data and results from studies investigating the interaction of genotypes and phenotypes in humans to assist scientists in discovering associations between genetic variants and risks for disease. Responsibilities of the dbGaP Genotypes Curator will include genotype analysis pipeline development, data reformatting, data quality control, management of a relational database, data curation, and communication with external investigators. This is an opportunity to be involved in the advancement of a high-profile resource that is working to revolutionize human genetic disease research.
 

Requirements:

  • Ph.D. or M.S. or sufficient experience in genetic linkage analysis and/or allelic association studies
  • Experience analyzing human genotype data
  • Scripting experience in Python or Perl
  • Relational database experience (SQL)
  • Linux/UNIX experience
  • Ability to work with a team in a production environment and communicate well with NCBI biologists and programmers as well as external scientists
  • Strong interest in contributing to the development of public database resources
  • Advanced general computing skills
  • Knowledge of PLINK software and VCFtools

 Other Desirable Experience:

  • Human genetics
  • Haplotypes
  • Analysis of structural variations
  • Copy number variation
  • QA filtering of genotype data (HWE, non-Mendelian segregation)
  • Experience with dbSNP

Computercraft offers a competitive salary, an excellent benefits package, and the opportunity for a positive work–life balance with a standard 40-hour work week and the chance to work alongside a team of highly accomplished professionals.

Computercraft is an equal opportunity employer. 



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