About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.
Staff Scientist | X-Ray Crystallography Core
Position Summary and Key Responsibilities:
City of Hope has a proven track record for translating our discoveries into life-saving medicines, playing a fundamental role in the development of recombinant insulin, humanization of monoclonal antibodies and CAR T cell therapies (with core patents covering each). The institute has over 27 core facilities with three FDA-approved/CA-licensed GMP facilities (small molecules, biologics and cellular therapies). Over the years, it has built a culture of communication between the clinicians and research faculty and a sense of urgency to treat and cure patients with cancer and diabetes.
The ideal candidate will be a self-starter that likes to work with other PIs across the institute. Projects that come to the core vary widely from de novo structure determination to protein-protein interactions to fragment screening and rational drug design. X-ray crystallography experience is absolutely required. Outstanding communication skills are also a must. The core houses a Rikagu 007HF, a mosquito crystallization robot, and two Formulatrix's imagers. In addition, the core has a Biacore T200, Water nanoITC, a Beckman XLI, Jasco 810 CD/fluorimeter and a Kinexa3000. All instruments are under vendor service contracts. The core also provides protein production using multiple expression systems as well as purification. The candidate will work closely with other core staff as well as other City of Hope cores involved with translational medicine (i.e., computational, HTS, synthetic chemistry, and mass spectrometry cores.)
City of Hope is located in Duarte, just a few miles away from Pasadena and close to all the major attractions of Los Angeles and Southern California, yet the campus is less than 10 minutes away from the San Gabriel mountains and numerous hiking trails (one as high as 10,000ft). The salary and benefits are highly competitive and the work is highly disciplinary.
Minimum Education and Skills Required for Consideration:
- A Ph.D. or other related doctoral level degree, required.
- The ideal candidate will be a self-starter that likes to work with other PIs across the institute. Projects that come to the core vary widely from de novo structure determination to protein-protein interactions to fragment screening and rational drug design. X-ray crystallography experience is absolutely required. Outstanding communication skills are also a must.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.